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IONTAS announces a new collaboration to identify novel immunotherapy targets


19th May 2020
IONTAS Limited, a specialist in the discovery and optimization of fully human antibodies, has entered into a collaboration agreement with Inotrem, a specialist in immunotherapy for acute and chronic inflammatory syndromes. As part of the agreement, IONTAS will apply its Mammalian Display technology to identify antibodies involved in the TREM-1 pathway.
 
TREM-1, an immunoreceptor expressed on innate immune cells, has been identified by Inotrem as a key therapeutic target for many acute or chronic inflammation syndromes, including sepsis and myocardial infarction. Under the terms of the collaboration, Inotrem will have access to IONTAS’ proprietary Mammalian Display platform, enabling specific high-affinity antibodies with optimal biophysical properties to be selected, to support the company in developing TREM-1 inhibition-based therapies more efficiently, with reduced chemistry, manufacturing and control (CMC) risk.
 
IONTAS’ Mammalian Display technology facilitates an increase in the probability and speed of antibodies successfully progressing into cell line development and manufacture. The platform screens antibodies in IgG format, in context of a mammalian cell, allowing researchers to assess lead candidate function, expression and developability early in the discovery process. In addition, large numbers of clones can be screened using fluorescence-activated cell sorting (FACS) in comparison to a low-throughput ELISA.